Django is a high-level Python Web framework that encourages rapid development and clean, pragmatic design.
Ridiculously fast + Reassuringly secure + Exceedingly scalable
TurboGears 2 is a reinvention of the TurboGears project to take advantage of new components, and to provide a fully customizable WSGI (Web Server Gateway Interface) stack.
Free open source full-stack framework for rapid development of fast, scalable, secure and portable database-driven web-based applications. Written and programmable in Python
Flask is a Python framework available under the BSD license. It was inspired by the Sinatra Ruby framework. Flask depends on the Werkzeug WSGI toolkit and Jinja2template.
Bottle is a microframework. Originally meant for building APIs, Bottle implements everything in a single source file. It has no dependencies apart from the Python Standard Library. Coding with Bottle gets you closer to the metal than coding with any full-stack framework.